Abstract
CLINICAL EVALUATION OF SHIGELDYSENT AND CIPROFLOXACIN IN THE TREATMENT OF SHIGELLOSIS

Tasneem Qureshi, Aftab Saeed1, Khan Usmanghani and Hafiz Muhammad Asif*

ABSTRACT

Objective: A comparative randomized controlled clinical trial was undertaken to evaluate the effectiveness of herbal coded formulation “ShigelDysent” in comparison with Ciprofloxacin for the treatment of Shigellosis in order to establish an appropriate safe and effective traditional medicine for Shigellosis. Methods: Two hundred and fifty patients were enrolled in the study and divided into two groups according to treatment regimen. Ciprofloxacin was given to 125 patients (Control Group) as a control drug and ShigelDysent was prescribed to 125 (Test Group). Stool culture was examined before and after treatment. Results: Test drug (ShigelDysent) was found to be more effective in controlling Shigella dysentery by eradicating more Shigella species, as 75% of Shigella colonies were absent in test group as compared to control in which 59% of Shigella colonies were absent after treatment. Conclusion: ShigelDysent has been found to be more effective in comparison with Ciprofloxacin for the treatment of Shigellosis. There were no side effects associated with the treatment by ShigelDysent and this is found to have good acceptability by all treated patients.

Keywords: Shigellosis, traditional medicine, efficacy, ShigelDysent, Ciprofloxacin.


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