CLINICAL EVALUATION OF SHIGELDYSENT AND CIPROFLOXACIN IN THE TREATMENT OF SHIGELLOSIS
Tasneem Qureshi, Aftab Saeed1, Khan Usmanghani and Hafiz Muhammad Asif*
ABSTRACT
Objective: A comparative randomized controlled clinical trial was
undertaken to evaluate the effectiveness of herbal coded formulation
“ShigelDysent” in comparison with Ciprofloxacin for the treatment of
Shigellosis in order to establish an appropriate safe and effective
traditional medicine for Shigellosis. Methods: Two hundred and fifty
patients were enrolled in the study and divided into two groups
according to treatment regimen. Ciprofloxacin was given to 125
patients (Control Group) as a control drug and ShigelDysent was
prescribed to 125 (Test Group). Stool culture was examined before and after treatment.
Results: Test drug (ShigelDysent) was found to be more effective in controlling Shigella
dysentery by eradicating more Shigella species, as 75% of Shigella colonies were absent in
test group as compared to control in which 59% of Shigella colonies were absent after
treatment. Conclusion: ShigelDysent has been found to be more effective in comparison with
Ciprofloxacin for the treatment of Shigellosis. There were no side effects associated with the
treatment by ShigelDysent and this is found to have good acceptability by all treated patients.
Keywords: Shigellosis, traditional medicine, efficacy, ShigelDysent, Ciprofloxacin.
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