Abstract
REVIEW ARTICLE: BREAST CANCER AND MELATONIN

*Raheja R. and Tirth A.

ABSTRACT

Breast cancer is one of the most frequently occurring cancers among women and one of the leading causes of death among women aged 40 to 55 years. Chemoprevention is one such strategy that involves administration of drugs to prevent, suppress, or reverse the carcinogenesis process. In breast cancer management, chemoprevention is aimed at preventing mammary cancer progression to invasive cancer. In a breast cancer prevention trial using tamoxifen, its use resulted in a 49% reduction in the incidence of estrogen receptor (ER)– positive breast cancers in high-risk women. Pineal gland and melatonin are likely to play an important role in the pathogenesis of breast cancer. Decrease in pineal function, whatever its cause, and the consequent reduction in melatonin secretion could induce a state of relative hyperestrogenism, thus leading to a prolonged exposure of breast tissue to estrogens and eventually ending in cancer induction.

Keywords: Breast cancer, Estrogen, Indoleamine, Melatonin, Progesterone.


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