Meena Kurup* and Arun Raj R.


Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration. The particle technology involves several approaches from the conventional size reduction processes to the Novel particle technology that modify the solubility properties of the drugs and produce solid, powdered form of the drugs that are readily soluble in water and can be easily formulated into various dosage forms. This review highlights the advantages of anti-solvent crystallization for improving solubility, dissolution and bioavailability of drugs with poor aqueous solubility. An anti-solvent crystallization technique is being used to prepare nanoparticles or micro particles for poorly water soluble drugs at research scale. This method has an ability to change the solid-state properties of pharmaceutical substances including the modification of crystal formation and particle size distributions. Therefore, various operating variables, their effect on the particle size of poorly water soluble drugs in an anti-solvent crystallization and problems related to anti-solvent crystallization have been reviewed.

Keywords: Anti-solvent crystallization, Problems, Oil out, Operation variables.

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