Abstract
ROLE OF HYPERTHERMIA, IN COMBINED TREATMENT OF CANCER

Rahul Gurjar, Rajababu Sahu, Ramgopal Yadav, Ramkumar Ahirwar and Pushpendra K. Khangar*

ABSTRACT

Hyperthermia, the procedure of raising the temperature of tumour-loaded tissue to 40–43°C, is applied as an adjunctive therapy with various established cancer treatments such as radiotherapy and chemotherapy. The potential to control power distributions in vivo has been significantly improved lately by the development of planning systems and other modelling tools. This increased understanding has led to the design of multiantenna applicators (including their transforming networks) and implementation of systems for monitoring of E-fields (eg, electro-optical sensors) and temperature (particularly, online magnetic resonance tomography). Hyperthermia (HT) is one of the hot topics that have been discussed over decades. However, it never made its way into primetime. The basic biological rationale of heat to enhance the effect of radiation, chemotherapeutic agents, and immunotherapy is evident. Preclinical work has confirmed this effect. HT may trigger changes in perfusion and oxygenation as well as inhibition of DNA repair mechanisms. Moreover, there is evidence for immune stimulation and the induction of systemic immune responses. Despite the increasing number of solid clinical studies, only few centers have included this adjuvant treatment into their repertoire. However, for every particular temperaturedependent interaction exploited for clinical purposes, sophisticated control of temperature, spatially as well as temporally, in deep body regions will further improve the potential.

Keywords: Hyperthermia, Mechanism, Radiotherapy, Chemotherapy, Immunotherapy.


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