METHOD DEVELOPMENT FOR CHARACTERIZATION OF NOVEL COPPER CHELATORS IN PATIENTS WITH DIABETES
Sakshi Mourya, Saksha Sahu, Saily Lodhi, Sajjad Ahmad and Imran Khan*
ABSTRACT
Defective copper regulation is implicated as a causative mechanism of organ damage in diabetes. Treatment with
trientine, a divalent-copper-selective chelator, improves arterial and renal structure/function in diabetes, wherein it
also ameliorates left-ventricular (LV) hypertrophy. Oxidative stress and mitochondrial dysfunction have been
identified by many workers as key pathogenic mechanisms in ageing-related metabolic, cardiovascular and
neurodegenerative diseases (for example diabetes mellitus, heart failure and Alzheimer's disease). Copper is a
fundamental element for the homeostasis of the body. It is the third most abundant essential transition metal in
humans. On the other hand, excessive exposure to copper can cause toxicity in many human organs, leading to
various systemic alterations. In the kidney, increased copper concentration in the blood can cause deposition of
this element in the kidneys, leading to nephrotoxicity. One of the most interesting aspects of copper balance is its
influence on diabetes and the progression of its complications, such as Diabetic Kidney Disease (DKD). Several
studies have shown a close relationship between copper serum levels and altered glycemic control. An imbalance
of copper can lead to the progression of diabetes-related complications and impaired antioxidant homeostasis. The
aim of this review is to evaluate the possible role of copper in DKD patients. TETA prevents tissue damage and
causes organ regeneration by acting as a highly-selective CuII chelator which suppresses copper-mediated
oxidative stress and restores anti-oxidant defenses. My group has employed TETA in a comprehensive
programme.
Keywords: Diabetic Kidney Disease; Copper; Diabetes; Zinc; Diabetic nephropathy; Chronic kidney disease.
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