Abstract
SERUM GAMMA-GLUTAMYL TRANSFERASE LEVELS IN PREDIABETES AND DIABETES MELLITUS PATIENTS

Vatsal Vyas*, Nirav Chavda, Shraddha Panchal, Jay Shingala, Ammara Quraishi and Abhishek Vadher

ABSTRACT

Introduction: Gamma glutamyl transferase is an enzyme which catabolizes glutathione. Hence increased levels of gamma glutamyl transferase are proposed to be associated with dysfunctions of many systems and can possibly predict the progression of diabetes mellitus. Methods: 164 participants who where first degree relatives of patients of type 2 diabetes were taken. Those with co-morbid conditions were not included in the study. Participants were divided into non-diabetics, pre-diabetics and diabetics based on the criteria by American Diabetes Association. Detailed physical examination, GGT levels and glucose tolerance test were performed on the patients. All the information was recorded and then statistical tests were performed. Student’s t test was used. P value of <0.05 was considered to be statistical significant. Results: The baseline characteristics of all the participants were noted in table 1. Average HbA1c was calculated to be 6.7±1.5. The mean level of GGT in non-diabetics was 19.7±9.7. The mean level of GGT in pre-diabetics was 41.8±9.5 and the mean level of GGT in diabetics was 44.9±11.3 (p value = 0.001). Conclusion: Our study shows that measuring the levels of GGT may be useful in assessing the risk of diabetes in first degree relatives of known cases of diabetes type 2.

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