SERUM GAMMA-GLUTAMYL TRANSFERASE LEVELS IN PREDIABETES AND DIABETES MELLITUS PATIENTS
Vatsal Vyas*, Nirav Chavda, Shraddha Panchal, Jay Shingala, Ammara Quraishi and Abhishek Vadher
ABSTRACT
Introduction: Gamma glutamyl transferase is an enzyme which catabolizes glutathione. Hence increased levels of
gamma glutamyl transferase are proposed to be associated with dysfunctions of many systems and can possibly
predict the progression of diabetes mellitus. Methods: 164 participants who where first degree relatives of patients
of type 2 diabetes were taken. Those with co-morbid conditions were not included in the study. Participants were
divided into non-diabetics, pre-diabetics and diabetics based on the criteria by American Diabetes Association.
Detailed physical examination, GGT levels and glucose tolerance test were performed on the patients. All the
information was recorded and then statistical tests were performed. Student’s t test was used. P value of <0.05 was
considered to be statistical significant. Results: The baseline characteristics of all the participants were noted in
table 1. Average HbA1c was calculated to be 6.7±1.5. The mean level of GGT in non-diabetics was 19.7±9.7. The
mean level of GGT in pre-diabetics was 41.8±9.5 and the mean level of GGT in diabetics was 44.9±11.3 (p value
= 0.001). Conclusion: Our study shows that measuring the levels of GGT may be useful in assessing the risk of
diabetes in first degree relatives of known cases of diabetes type 2.
Keywords: .
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