COMPOSITE ALGINATE HYDROGEL MICROPARTICLEDELIVERY SYSTEM FOR ZIDOVUDINE BASED ON COUNTERION-INDUCED AGGREGATION: INFLUENCE OF VARIOUS GRADES OF POLYACRYLATE AND HYPROMELLOSE POLYMERS
Beebireddy Vidhya*, Aenugu Jyothi, Gandrathi Srujana, Jestadi Ragaswetha, Vadladi Nikhila and Nelluri
Swarna
ABSTRACT
In the present research endeavor, Zidovudine Microparticles were attempted to reduce the frequency of dosing and
to attain steady-state drug levels. Zidovudine an anti-retroviral drug was selecte dasanovel drug for the
experiment. Different batches of zidovudine microsphere formulation Fl to Fl6 were developed using different
polymers like eudragit RS-100, eudragit RL-100, andhydroxylpropyl methyl cellulose (HPMC K4m premium)
propyl methyl cellulose (HPMCK 15M), swelling agent like sodium alginate and crosslinking agents like calcium
chloride (cacl2), bariumchloride(bacl2) at variousratios. Allthebatchesof theformulated zidovudine microparticles
from Flto Fl6 were evaluate for various physic chemical parameters like mean particle size distribution,
percentage yield, and drug entrapment efficiency. The entrapment efficiency of the formulations F1 to F16 ranges
from 52.43% to 62.35%. Invitro release studies were carried out on all the formulation using pH7.4phosphate
buffer as the dissolution medium. Thed uration of the drug release was 12hours. Based on the results of the physic
chemical characterization and in vitro drug release studiesof all the batches of the formulated microspheres from
Fl to FI6 formulation F11 was chosenas the most satisfactory formulation as it possessed all the required physic
chemical characters and prolonged duration of the drug release up to 8hours.
Keywords: Zidovudine, Microparticles, Ionotropicgelationtechnique, Polymer, FTIR Studies, In vitro drug release studies.
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