Abstract
ANTI UROLITHIATIC ACTIVITY OF WHOLE PLANT EXTRACT OF PERGULARIA DEAMIA AGAINST ETHYLENE GLYCOL INDUCED UROLITHIATIC RATS

S. Suman*, S. V. Suresh Kumar and S. Suma

ABSTRACT

The whole-plant, Pergularia daemia (Family: Asclepediaceae), extract was investigated for it’s antiurolithiatic. Ethylene glycol (0.75% in water) feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Pet-ether extract (100 and 200mg/kg) of P. daemia was given orally in curative and preventive regimens over a period of 28 days. Supplementation with extract significantly (P < 0.001) lowered the urinary excretion and kidney retention levels of oxalate, calcium and phosphate. Furthermore, high serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extract. The results were comparable with the standard drug, cystone (750 mg/kg). The reduction of stoneforming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of the extract.

Keywords: Pergularia daemia, Ethylene glycol, Cystone, Anti-Urolithiasis.


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