European Journal of Biomedical and Pharmaceutical Sciences

A COMPARATIVE STUDY OF SEVOFLURANE, HALOTHANE AND ISOFLURANE IN PAEDIATRIC PATIENTS

H.D. Rajguru, Dr. Amita Kubavat, S.M. Malek*, I.A. Chadhdha, D.D. Rajguru, H.R. Purohit, K.N. Hajare, T.V. Hadvani

ABSTRACT

Introduction: Sevoflurane is relatively newer inhalation anesthetic agent as compared to previously used Halothane and Isoflurane. The major problems associated with pediatric patients are smooth and safe maintenance of the airway. Methodology: Present study is a prospective, randomized comparative study conducted within two year of time.60 pediatric patients are enrolled, undergoing a variety of surgical operations are randomly allocated in equally divided 3 groups based on induction inhalation agents like sevoflurane, halothane and Isoflurane. Results: Data shows that breath-holding was observed in each group, while laryngospasm was found in one case each in group Sevoflurane and Isoflurane, and 1 case of bronchospasm found Halothane group. Discussion: Pediatric anesthesia is an ever-challenging task especially for small children where intravenous canulation is difficult prior to anesthesia. Sevoflurane is better and acceptable alternative to halothane as it provides faster induction and recovery in children due to non-pungency and rapid psychomotor orientation.[2] Sevoflurane is an acceptable alternative to Halothane. The mean induction time of halothane was significantly more as compared to sevoflurane group.

Keywords: Comparative study, Sevoflurane, Halothane Isoflurane, Paediatric patients.