Abstract
DOUBLE HYPHENATED TECHNIQUES: AN OVERVIEW

Dr. Jayanti Mukherjee*, B. Pavani , L. Noel, Atika Afreen

ABSTRACT

A separation method and a spectroscopic detection method are combined to create the hyphenated methodologies like GC-MS, LC-MS, LC-FTIR, LC-NMR, CE-MS to name a few. A hyphenated methodology combines or couples two distinct analytical methods with the use of an appropriate interface. The majority of these combinations use chromatographic and spectroscopic methods. The phrase "hyphenated methods" refer to the fusion of identification, separation, and identification approaches. Better component analysis results from the hyphenation of these methodologies. Hyphenated methods demonstrate sensitivity and specificity. Fractions of the chemical components of a mixture that are pure or virtually pure are produced via chromatography. Different chemical and instrumental techniques that are involved in drug estimation are created periodically so that medications would perform their intended purposes. Spectroscopic methods like NMR, MS, and IR are utilised for identification whereas chromatographic methods like GC, LC, etc. are employed for separation. Pharmaceuticals can acquire contaminants throughout the different stages of development, transit, and storage making them dangerous to administer. So, these hyphenated techniques are useful to detect the impurities and save the patients from toxicities.

Keywords: GC-MS, LC-MS, LC-FTIR, LC-NMR, CE-MS, GC-IR


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