Rita Ganava*, Reena Ganava, R. R. Kanhere and Hemant Pandit


Endosulfan is one of the most disputed toxic pesticides and is responsible for many severe pesticide poisoning incidents around the world. The present study is aimed to find out the effects of this pesticide on whole body oxygen consumption and protein and glycogen content of the liver a fresh water fish, Tilapia mossambica. The toxicity tests were conducted by static renewal bioassay method on the juveniles of fish Tilapia mossambica (Peters). The probit analysis showed that the LC50 (lethal concentration) value of endosulfan (Thiodan 35 EC® ) for 24, 48, 72 and 96 h were 0.9, 0.5, 0.1 and 0.05ppm for 96 hours. The teleost fish Tilapia mossambicus of 15±1g was exposed to three different sub lethal concentrations of Thiodan 35 EC® for 24,48,72,96 hours. Hepatic metabolic parameters like protein and glycogen were also determined. Results clearly shown that rate of oxygen consumption were declined along with the increase of dose and duration. Decrease in both in respiratory rate and in body weight (P<0.05) was also observed in all treated groups. One third (30 μg/L) one tenth (5 μg/L) and one fifth (10 μg /L) of the LC50 values were selected for sub lethal studies. An initial increase in the oxygen consumption was observed in low sub lethal concentrations (1/5th and 1/10th exposure) but thereafter a sharp decrease in oxygen consumption was observed in all sub lethal concentrations. Results also clearly revealed that protein, glucose and glycogen content of liver were significantly reduced in all experimental groups treated with sub lethal concentrations of endosulfan. The reduction in glycogen content of liver in all the experimental fishes might be due to the utilization of carbohydrates for energy production as a result of toxicant induced hypoxia was observed which has also been reflected in reduction in oxygen consumption. Fish under sub lethal concentration were found to be under stress and duration of the exposure is found to be an important factor for inducing the toxic effects. Hence, respiratory dysfunction and hepatic metabolic markers like glucose and glycogen can be used as an index of Parathion toxicity.

Keywords: Pesticide, Endosulfan, glycogen, Tilapia mossambica, oxygen consumption.

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