European Journal of Biomedical and Pharmaceutical Sciences

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF LUMEFANTRINE AND ARTEMETHER IN BULK AND TABLET DOSAGE FORMS

Chadalavada Swathi*

ABSTRACT

Typically, analytical methods are necessary to determine the identification, potency, quality, and assay of drug material, drug product, and contaminant. Examining pharmaceutical and biological samples may aid biopharmacokinetics researchers in identifying the presence of drugs and their metabolites.[1] Lumefantrine is a member of the fluorenes family and has the formula 9-(p-chlorobenzylidene)-9H-fluorene. It contains chlorine atoms at locations 2 and 7, as well as a 2-(dibutylamino)-1-hydroxyethyl group at position 4. Used in combination with artemether to treat resistant falciparum malaria. It is beneficial because it prevents malaria. It is a member of the tertiary amine, monochlorobenzene, secondary alcohol, and fluorene families. Artemether, an artemisinin derivative, is artemisinin with the lactone substituted by lactol methyl ether. It is an antimalarial used in concert with lumefantrine to treat resistant strains of falciparum malaria. It is beneficial because it prevents malaria. It consists of artemisinin, a semisynthetic sesquiterpenoid, cyclic acetal, organic peroxide, and a semisynthetic acetal.

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