FORMULATION AND EVALUATION OF HYALURONIC ACID NIMESULIDE GELS
B. Nagamani*, Revathi Ramani, Tata. VS Santosh Kumar and P. Umadevi
ABSTRACT
Hyaluronic acid is a polymer of disaccharide, themselves composed of D Glucuronic acid and D-N
acetylglucosamine, linked via alternating β-1,4 and β-1,3 glycosidic bonds. In the Present work an attempt is made
to prepare HA gels containing Nimesulide. the gels prepared are subjected to extensive rheological evaluation,
drug content estimation, pH measurement, stability study and drug release study across hairless albino skin rat.
The influence of various permeation enhancers on rat skin permeation was studied. The major outcomes of the
research are as follows. Gels prepared using HA revealed a pH of 6.45. Since HA is a component of the human
skin no hypersensitivity reactions can be expected when used as a carrier in preparation of topical gels. During its
shelf life, rheological evaluation studies indicated that there is no significant change in the viscosity of the
formulation. The prepared HA gels had a greater initial rate of permeation as compared with the marketed
formulations. From the results of the experiment. we can expect a superior onset of therapeutic action as compared
with the marketed formulation. Since HA is an endogenous component involved in cellular signaling, wound
repair, morphogenesis and matrix organization these gels do not cause skin irritation and hypersensitive reactions.
The rate of skin permeation of the drug increased with increasing concentration of the permeation enhancer
(PEGs) until a certain threshold value. At very high concentrations of the permeation enhancer, the rate of
permeation has decreased suggesting intramolecular attraction of the PEGs thus limiting the rate of permeation.
Keywords: Hyaluronic acid (HA), Rat skin Permeation , Poly ethylene glycol (PEG), HA gels, Rheological studies.
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