European Journal of Biomedical and Pharmaceutical Sciences

SCIENTIFIC EVALUATION OF PRESENCE OF FUNCTIONAL GROUPS IN SIDDHA MEDICINE THAZHUTHALAI ILAI CHOORANAM THROUGH FOURIER TRANSFORM INFRARED SPECTROSCOPIC STUDY

M. Manibharathi* and A. Manoharan

ABSTRACT

Background: The Siddha system of medicine is the most primitive medical system. The philosophy of siddha medicine is based on these principles of vadham, Pitham, Kabam. Siddha medicine not only cures the diseases but also explain the method of preventing the diseases. Kumbavadham is one of the vadha diseases(Periarthritis). Thazhuthalai ilai chooranam is a mono-herbal drug indicated for kumbavadham, mentioned in a classical siddha literature Gunapadam mooligai vaguppu. Aim: The aim of the study to assess the morphology and elemental characterization of thazhuthalai ilai chooranam. The functional groups of drug formulation are analysed through FT-IR Spectroscopy and pharmacological roles of functional groups are discussed in this study. Materials and Methods: The raw drugs are collected and purified then ground into micronized powder. The drug was subjected into characterization through FT-IR analysis. Results: The FT-IR analysis showed the presence of functional groups that are O-H Stretching(carboxylic acid, alcohol), O-H bending (carboxylic acid ,alcohol), N-H Stretching(Amine salt), N-H Bending(Amine), C=C Stretching (Alkene, conjugated alkene, cyclic alkene), S=O Stretching(sulphate), C=N Stretching(Amine), C-O Stretching (Aliphatic ether, secondary alcohol), C-Br Stretching(Halo compound). C=C Bending (Alkene), C-I Stretching (Halo compound) which are ensures the therapeutic efficacy of drug. Conclusion: The analysis of FT-IR Study for Thazhuthalai ilai chooranam showed the presence of functional group through the stretching and bends which is responsible for biological activity. The Pharmacological effects of Thazhuthalai ilai chooranam is due to Carboxylic acid, Alkene, Halocompound, Amine, Amine salt, Sulphate. This will assure the efficacy and therapeutic effect of the drug. This FT-IR Study will be very useful for the further study of Thazhuthalai ilai chooranam.

Keywords: FT-IR, Thazhuthalai ilai chooranam, Siddha medicine, Functional groups, Kumbavadham, Periarthritis.