Jibrin Yusuf Dahiru*, Firdausi Aliyu Abubakar and Hamza Idris


Antibiotic resistance is one of the greatest treats to modern health and we face a feature without cures for infection if antibiotics are not used responsibly. Penicillin is one of these antibiotics which microorganism is coming resistant to. To resolve the problems of antibiotics resistance the present thesis was an effort to study the activity of commonly used penicillin on some clinical bacterial isolate. The commonly used penicillins include ampicillin, amoxicillin, oxacillin, cloxacillin and augumentin. While the clinical bacterial isolate include Escherichia coli, staphylococcus aureus, klebsiella, proteus, pseudomonas aeruginosa, streptococcus pneumonia etc. The susceptibility of the test organism to test antibiotics was determined, antimicrobial strength and spectrum of the penicillin antibiotics on the bacterial isolate was determine and also the pattern of in-vitro antimicrobial sensitivity of the test antibiotic on susceptible isolate was determine. The test isolate collected were confirmed using biochemical test and then inoculums of these organism was prepared and standardized using marcfarland, disc diffusion technique was used for the bioassay. Even though more than 50% of the organism show resistance to penicillin, the current result indicate that augumentin has the broadest spectrum of activity on both Gram positive and Gram negative organism (45.45%), pseudomonas aeruginosa emerges to be the most resistant organism (only 13.84% are sensitive to the test antibiotic), While staphylococcus aureus was the most sensitive organism. Antibiotic need to be used when it becomes necessary and there is need for proper usage according to the recommended dose.

Keywords: penicillin, microorganism, inoculums, resistance and sensitivity.

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