Abstract
NANOEMULGEL”-A BRIDGE BETWEEN NANOTECHNOLOGY AND DERMATOLOGICAL APPLICATION: A REVIEW

S. K. Apeksha*, A. R. Shabaraya, and K. Vineetha

ABSTRACT

Nanoemulgel is a drug delivery system being explored for topical formulations. It consists of an emulsion incorporated into a gel base, which is prepared using a gelling agent. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced. It can also be targeted more specifically to the site of action and avoid first-pass metabolism. It solves major issues such as limiting the use of lipophilic drugs, poor oral bioavailability, and unpredictable pharmacokinetic and absorption variations. Nanoemulgel is a formulation-related intervention to improve drug absorption and the therapeutic profile of lipophilic drugs. It is widely used in the treatment of acne, pimple, psoriasis, fungal infection, and inflammation caused by osteoarthritis and rheumatoid arthritis. It can be delivered via ocular, vaginal, dental, and nose-to-brain routes for the treatment of diverse local and systemic ailments. Despite having a few limitations, nanoemulgel formulation is a potential and promising candidate for the topical delivery of lipophilic drugs in the future.

Keywords: Gels, Nanoemulsion, Nanoemulgel, Gelling agents, Hydrophobic drug.


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