European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF THE INSULIN RESISTANCE IN DIABETIC PATIENTS WITH DEPRESSIVE DISORDERS

Vipul Kumar Garg, Santosh Kumar Yadav, Suchi Diwedi and Kamlakar Tripathi*

ABSTRACT

Aim: To examine the association between depression and insulin resistance in diabetic patients. Objective: The key objective of this study was to examine the relationship between depression and insulin resistance in Diabetic patients. Global prevalence of diabetes was 2.8% in 2000 and it will reach 4.4% in 2030 to be 366 million diabetics. Many epidemiologic studies have shown that patient with diabetes are more susceptible to depression. Diabetes and depression align in a non-accidental way and complicate one another. Materials and methods: Total 120 individuals were enrolled from S.S. Hospital BHU India in 2013-2015 with their written consent form and divided in to four groups. Group 1 considered as healthy control, Group 2 only diabetic, Group3 only depression and Group 4 both diabetic with depression which follows the inclusion criteria of WHO and Diabetes Data Group. Our aim was to evaluate the prevalence of depressive disorders in patients with diabetes and to describe their socio demographic and clinical profile. Results: Total 120 individuals (mean age 45±14 years) were equally divided in four groups with equal male and female proportion. BMI was higher in group2 only diabetic (43.3%) than group 3 only depressive (46.7%) which were under wight. Where as in Group 4 Depression with diabetes have maximum (46.7%) were obese (p<0.015). In Group 4 More than (60%) 18 patients have 10-20 Insulin Resistance code. Group 3 only depression have maximum (56.7%) 17 Patients with 2-10 Insulin Resistance code (p<0.001). Conclusion: Patient having both depression and diabetes were found to be having greater insulin resistance than patients who had only diabetes. Patients having more BMI were found to be having more insulin resistance. Obesity and depression may contribute in insulin resistance hence needs consideration while prescribing oral hypoglycemic drug.

Keywords: Diabetes ? Depression ? Prevalence ? Dysthymia ?.