Abstract
ANTI-ULCER ACTIVITY OF CASSIA SIAMEA USING ETHANOL INDUCED GASTRIC ULCER IN RAT

P. Saranya*, K. Sanjay, M. Sowmiya, T. Santhosh Kumar, M. Santhosh and M. Sivasambanda Selvam

ABSTRACT

Background: An ulcer is a sore which means an open painful wound in mucous membranes or mucosal linings of the body. The cause of ulceration in patients is mainly due to hyper secretion of gastric juice and pepsin. In present, the peptic ulcer is seen among many people. The two most common type of peptic Ulcer are called ―Gastric ulcer‖ and ―duodenal ulcer‖. Objective: The objective of the study is determining the antiulcer effect from the fresh juice of rhizome of cassia siamea. The preliminary phytochemical screening of whole plant extract was indicates in potential in Antiulcer activity. Pantoprazole used as a standard comparison agents. Materials and Methods: Albino wistar rats of both sex having (150-200g) are divided into 5 groups of 6 animals each. They are housed in individual cages and fasted for 24hrs allowing free access of drinking water. Ulceration was induced in 36hrs without feeding the rat by the administration of 80% of ethanol orally in a dose of 1ml for each rat. Result: Ethanolic extract exhibited significant (p<0.001) antiulcer activity in ethanol induced gastric ulcer model. An antiulcer effect of ethanolic extract of cassia siamea have potential ability of Anti-ulcer activity.

Keywords: Anti-Ulcer, Cassia Siamea, Ethanol Extraction, Gastric Ulcer.


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