FORMULATION AND EVALUATION OF EUPATORIUM ODORATUM HERBAL OINTMENT
Mahesha Keerikkadu* and Suryanarayana K.
ABSTRACT
The enormous surface area and permeability of the skin play a significant influence in the distribution of drugs through it. The medications like ointments, creams are used for the treatment and caring of the skin. The aim present research study is to prepare the wound healing ointment and to evaluate the medicinal property of the Eupatorium odoratum (EO) Ointment. Eupatorium odoratum is rapidly growing natural herb which have the wound healing property is used in this study for the preparation of the herbal ointment. The extract collected form Soxhlet extractor was used for the analysis of phytochemicals. EO ointment is prepared by adding coconut oil and honey wax. The prepared ointment is evaluated by pH, separability and antimicrobial activity. The positive result of Tannins and Saponins supports the wound healing property of the sample and the presence of Diterpenes supports the antimicrobial property of the plant leaves. The ointments had a good appealing appearance with green color and smooth texture, and they were all homogenous with no signs of phase separation. The pH and spreadability were found to be 6.90±0.172 and 109.20±3.17 respectively. Antimicrobial activity of the EO ointment in different assay organisms and the inhibition of EO ointments is compared with the standard positive control. The result showed that EO ointments has the good antimicrobial properties. This study shows that EO has high potential as antimicrobial agent when formulated as wound healing ointment.
Keywords: Ointment, Eupatorium odoratum, Phytochemical analysis, antimicrobial activity, wound healing.
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