EVALUATION OF IN-VITRO ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACT OF GREWIA FLAVESCENS JUSS (EEGF) WHOLE PLANT
Dr. G.N. Pramodini*, Dr. Shaik. Mohd. Khasim, Sumaiya Firdouse, Rubeena Fatima, Syed Shanawaz and MD. Farhan Anwar
ABSTRACT
The Evaluation of Invitro Antimicrobial activity of Ethanolic Extract of Grewia Flavescens (EEGF) whole plant belonging to family Tiliaceae was traditionally known to be a herbal remedy for the treatment of pain, wound healing, antimicrobial, fever, urinary stones, intestinal infections but it did not claim to be a commercial drug as it did not have any scientific proof. The Present research work deals with the Antimicrobial activity which has been scientifically proven and compared with the standard drugs Ceftriaxone and Fluconazole to study the antimicrobial activity. The ethanolic extract of Grewia Flavescens has showed significant Antimicrobial activity. Ethanolic extract of whole plant of Grewia Flavescens were screened for their antimicrobial activity. The extract is tested against Gram positive organism Staphylococcus aureus ATCC25923, and Gram negative organisms Salmonella tophi ATCC-14028,Klebsiella pneumonia ATCC-33495 and a fungus candida albicans ATCC-66027. The Agar well diffusion method is used to determine the Minimum Inhibitory Concentration(MIC). All the EEGF has Significantly shown antimicrobial activity against Klebsiella pneumoniae and candida albicans as they has shown MIC value 75μg/ml whereas the MIC value of Staphylococcus aureus is 25μg/ml. The MIC value of 25 μg/mL for EEGF against S. aureus indicates that it is more potent than the standard drug Ceftriaxone, which has a MIC value of 50 μg/mL. Similarly, Fluconazole shows activity only against fungus Candida albicans, with a MIC value of 25 μg/Ml.
Keywords: Antimicrobial activity, Grewia Flavescens, Ceftriaxone and Fluconazole.
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