European Journal of Biomedical and Pharmaceutical Sciences

CORRELATION OF PULMONARY FUNCTION TEST WITH HRCT IN INTERSTITIAL LUNG DISEASES

Deepak Shah, *Wazid Hussain, Ishan Kumar, Shivam Dixit and Arya Krishnan

ABSTRACT

Background: Interstitial Lung Diseases (ILD) are a group of diffuse parenchymal lung diseases associated with substantial morbidity and mortality. ILD is an umbrella term for a large group of disorders that cause scarring (fibrosis) of lungs. The scarring causes stiffness in the lungs which makes it difficult to breathe. Some examples of ILD includes: Idiopathic pulmonary fibrosis, Hypersensitivity pneumonitis, Sarcoidosis, Asbestosis. Aim of this study: Aim of this study is to correlate the HRCT Thorax patterns and extent of involvement of ILD with pulmonary function test (PFT) and Six minute walk test (6MWT). Patients and Methods: This is a cross sectional study design which was conducted upon 60 patients of Interstitial Lung Diseases who were receiving medical treatment from Sir Sunderlal Hospital, BHU between July 2020 to June 2022. They are classified into 3 groups on the basis of predominant pattern on HRCT Thorax: a) Group I- Fibrotic Pattern, b) Group II- Ground glass pattern, c) Group III- Nodular pattern. Pulmonary function test including FEV1, FVC, FEV1/FVC, Six Minute Walk Test were done for all patients. Results: In this study total 60 patients with ILD were included, most of them were male (58.3%). 40% of the study population were smokers and mean age of study population was 51.06 years. Fibrotic pattern is more frequent HRCT pattern found in the study population (46.6%) followed by ground glass pattern (38.3%). Forced vital capacity (FVC) is lower in fibrotic pattern while FEV1/FVC ratio is lower in nodular pattern (FEV1 = Forced expiratory volume in first second). Six minute walking distance (6MWD) is lower in fibrotic pattern. Conclusion: HRCT Thorax patterns and degree of lung involvement in ILD have direct relation with pulmonary function tests. Lung volumes and Six minutes walking distance are lower in fibrotic pattern.

Keywords: ILD, PFT, HRCT, 6MWT, FVC, FEV1.