FORMULATION AND EVALUATION OF AQUASOMES OF DAPSONE FOR IMPROVED SOLUBILITY
Nikhil Shrivastava* and Sandeep Jain
ABSTRACT
The present dissertation has been undertaken with an aim to improve the efficacy of dapsone by incorporating on to aquasomes. The aquasome was prepared in three steps which included the preparation of calcium phosphate core which was coated with lactose and finally the drug was adsorbed on to the surface of the lactose coating. Optimization of the ceramic core was done by varying the sonication time and it was found that sonication for 90 min yielded the smallest particles with the least PDI. The optimized core was subjected to coating using three concentrations of lactose and to each of these coated core formulations (CC1-CC3) dapsone was adsorbed to obtain the aquasomes. The ceramic core and the coated core were found to be in the size range of 200-350 nm whereas the drug loaded aquasomes were found to be in the size range of 430-600 nm. The polydispersity index of the formulations was found to be around 0.7-0.9 for each category of sample. The drug content in the formulations was in the order F2>F1>F3 and was found to be 79.8% for F2, 76.3% for F1 and 72.0% for F3. The highest amount of drug was found to be released from F2 (88.12 ± 0.79%) at the end of the study (8h) duration while the lowest amount of drug was released from F3 (71.49 ± 0.74%).
Keywords: Dapsone, acne, ceramic core, release, solubility.
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