CUBOSOME AS DRUG DELIVERY SYSTEM: A REVIEW ARTICLE
Divyanshi Prakash* and Dr. Sunil K. Batra
ABSTRACT
Cubosomes, unique cubic-shaped particles formed by dispersing liquid crystalline clusters in water, offer a promising approach for drug delivery and have attracted significant interest in the field of pharmaceutical nanotechnology. This review creatively highlights the structural characteristics, merits and demerits of cubosomes. It discusses the use of amphiphilic lipids such as glycerol monooleate (GMO) and phytantriol in cubosome manufacturing, as well as the role of stabilizing agents in maintaining the stability of dispersed particles. The article further explores the two main approaches for cubosome preparation, namely the top-down and bottom-up methodologies, along with techniques such as high-pressure homogenization, probe sonication, spray drying, and heat treatment. Lastly, it introduces the concept of cubosomal precursor forms, which offer an alternative method for cubosome generation. This review is an attempt to provide a comprehensive overview of cubosomes and their potential applications in drug delivery systems.
Keywords: Cubosomes, Glycerol monooleate (GMO), Phytantriol (PHYT), Poloxamer 407, Top down method, Bottom up method.
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