European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION CHARACTERIZATION AND OPTIMIZATION OF BENDROFLUMETHIAZIDE CONTROLLED RELEASE MATRIX TABLETS USING VARIOUS POLYMERS

Sathepuri Vivek* and Dr. E. Hari Krishna

ABSTRACT

In the present study Controlled release matrix tablets of bendroflumethiazide is investigated to optimize drug release up to 24hrs. These tablets were prepared by wet granulation method using various polymers like Guar gum, Sodium Alginate, Eudragit-S100, Carnauba Wax, Ethyl Cellulose. The formulated Controlled release matrix tablets were evaluated for different parameters such as Drug-excipient compatibility studies, weight variation, thickness, hardness, content uniformity, In-vitro Buoyancy studies, In vitro drug release studies performed in 0.1N HCl for 2hrs, 22hrs in 6.8PH Phosphate buffer and the data was subjected to Zero order, first order, Higuchi release kinetics and Korsmayer peppas graph. All pre and post compression parameters were found to be within limits. From the drug release data among formulations F12 formulation was found to be optimized.

Keywords: Bendroflumethiazide, Controlled Release Matrix Tablets, Carnauba wax, Guar gum, Sodium Alginate, Eudragit S100, Ethyl Cellulose.