NEUROPROTECTIVE AND NOOTROPIC EFFECTS OF ETHANOLIC EXTRACT OF TERMINALIA CHEBULA
Akanksha Sonkar, Kamlesh Manohar Palandurkar, Kiran Rajendra Giri and *Anshuman Trigunayat
ABSTRACT
Background: Cerebrovascular accident (CVA) is a world leading cause of mortality and morbidity. Wide modalities of treatment have been used for that and one such modality is neuroprotection. Neuroprotective and Nootropic agents reduces negative consequences of neuronal damage following stroke and scavenges free radicals produced during reperfusion injury, which can even worse out the condition after CVA. Purpose: The existing research establishes Neuroprotective and Nootropic effects of T.Chebula against the cerebral ischemic reperfusion injury (acute) and scopolamine induce amnesia in rats so to establish a future treatment modality for injury after stroke and for cognitive disorders. Methods: Acute ischemia-reperfusion is induced by blocking of bilateral common carotid arteries for 30 mins thereafter reperfusion for 45 mins in Albino rats(Charles foster). Effects of T.chebula on lipid peroxidation, superoxide dismutase (SOD) and T-SH in forebrain regions in acute ischemia - reperfusion were evaluated. Nootropic Effect of T.Chebula was evaluated on scopolamine induced amnesia (1mg/kg s.c) via passive avoidance, elevated plus maze and water maze test. Results: Pretreatment of rats with T.Chebula at a dose of 100 mg/kg p.o for 14 days reversed the biochemical variations produced by reperfusion. Scopolamine persuaded amnesia accompanied by deficits in learning were also attenuated with T.Chebula treatment. Conclusion: The results imply that T.chebula might be useful in neurodegenerative ailments and cerebrovascular insufficiency.
Keywords: T.chebula; Cerebral ischemic Reperfusion injury; Oxidative stress; nootropic; Cognition.
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