DEVELOPMENT AND CHARACTERIZATION OF POLYHERBAL GEL FOR ANTIBACTERIAL ACTIVITY
Om Rai*, Dr. Kaushelendra Mishra, Ashish Chourasiya and Dr. Mehta Parulben D.
ABSTRACT
In the Indian system of medicine-Ayurveda, Albino vereduna, Lens culinaris and Murraya koenigii has been mentioned as a remedy for treatment of various infectious diseases and ailments. Based on the folkloric use, the present study was designed to formulate and evaluate polyherbal gel containing extracts of Albino vereduna, Lens culinaris and Murraya koenigii. Gel formulations (Formulation PHG1, PHG2, PHG3, PHG4, PHG5 and PHG5) were prepared which comprised of the hydroalcoholic extracts of Albino vereduna, Lens culinaris and Murraya koenigii in a concentration of 1 gm in a base. The prepared formulations were evaluated for appearance, homogeneity, pH, viscosity, spreadability and washability. The formulations were also screened for their antimicrobial activity by disc plate method against Staphylococcus aureus and E. coli. The results of the studies revealed that all formulations under study showed better zone of inhibition as compared with the control. However, formulation PHG5 exhibited maximum activity against the selected strains which may be attributed toits greater amount of herbal extracts as compared to other formulations. The polyherbal gel formulations were observed to possess antimicrobial action. The effective activity may be attributed to the synergistic action of the plants constituents present in the formulation.
Keywords: Antimicrobial activity, Evaluation test, Murraya koenigii, Polyherbal gel.
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