Abstract
EFFECT OF FERMENTED PAPAYA PREPARATION ON DOXORUBICIN INDUCED HEPATOTOXICITY AND NEPHROTOXICITY

Bhavya N. Barot, Jaymesh M. Thadani, Ansarullah, Sunita P. Salunke*

ABSTRACT

Doxorubicin (DOX) is an anthracycline derivative used as an anticancer agent. However, its clinical use is limited due to its severe toxic manifestations. In the present study, we aim to evaluate the protective role of Fermented papaya preparation (FPP) in combating doxorubicin induced oxidative stress. Wistar rats were pretreated with FPP (100 mg/kg bw or 250 mg/kg bw) or saline daily for 28 consecutive days followed by doxorubicin (10 mg/kg bw) induction for next 2 days. Results indicated that pretreatment with FPP significantly decreased serum levels of hepatic markers Serum Glutamate-Pyruvate Transaminase (SGPT) and Serum Glutamate Oxalicacetic Transaminases (SGOT) along with renal marker Creatinine. Further, FPP supplementation significantly increased Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Reduced Glutathione (GSH) (p<0.05) while decreased Malondialdehyes and Calatase levels in kidney and liver. Histological observations demonstrated that FPP pretreatment attenuated DOX induced thickening of the glomerular basement membrane and destructive changes in the renal tubule as well as loss of tissue structural pattern and vacuolization in liver. Thus our results suggest that FPP exhibits significant preclinical potential in combating DOX induced oxidative stress.

Keywords: Doxorubicin, Fermented papaya preparation, Organ toxicity, Oxidative stress Liver, Kidney.


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