European Journal of Biomedical and Pharmaceutical Sciences

HEPATOPROTECTIVE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF CALYCOPTERIS FLORIBUNDA ON ATORVASTATIN INDUCED HEPATOTOXICITY – A REVIEW STUDY

*Sreenu Thalla, Polimera Chaitanya Sai, Bathula Siva Kumar, Anil Kumar Yerragopu, Bhavani Pentela, Rama Rao Nadendla

ABSTRACT

The hepatoprotective activity of the hydroalcoholic extract of Calycopteris floribunda in the context of atorvastatin-induced hepatotoxicity. The study aimed to assess the potential of the extract in ameliorating the adverse effects of atorvastatin on the liver. Hepatotoxicity induced by atorvastatin has been a concern, and natural remedies such as plant extracts have shown promise in mitigating drug-induced liver damage. In this investigation, various parameters including biochemical markers, histopathological analysis, and antioxidant enzyme levels were evaluated to determine the protective effect of Calycopteris floribunda extract. The results indicated a significant reduction in hepatotoxicity markers and preservation of liver architecture in the extract-treated group compared to the atorvastatin-only group. Moreover, the extract exhibited antioxidant properties, as evidenced by the restoration of antioxidant enzyme levels. These findings underscore the potential hepatoprotective activity of Calycopteris floribunda extract against atorvastatin-induced hepatotoxicity, suggesting its therapeutic relevance in managing drug-induced liver injuries. Further research is warranted to elucidate the underlying mechanisms and to explore the extract's potential as an adjuvant therapy in liver health management.

Keywords: Calycopteris floribunda, hepatoprotective, hepatotoxicity, atorvastatin.