European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON IN-SITU GELLING IN OCULAR DRUG DELIVERY SYSTEM

Pidugu Soudhamini, Sanike Saisnehanjali, Nida Tahreen Hafez, Potta Jhansi and R. Prasanthi*

ABSTRACT

Polymeric formulations known as "in situ gelling systems" transition from their sol state before entering the body to their gel state once inside it. The pH shift, temperature modulation, solvent exchange, UV radiation, and the presence of certain ions or molecules are only a few of the stimuli that can cause the sol-gel transition. Such characteristics make drug delivery systems well suited for preparing bioactive compounds for sustained distribution. The eye is the body's most sensitive organ. There are significant efforts being made to develop innovative drug delivery systems for ophthalmic administration in order to increase the bioavailability of ophthalmic medications. The efficiency of drug administration is increased by altering the release profile, and these innovative drug delivery methods also lessen drug toxicity, giving them a number of advantages over conventional systems. There is a lot of research being done in this field that supports the idea that in situ gelling systems can be useful for the administration of ocular medications. This study will provide a brief overview of in situ gels, distinct in situ gelling system techniques, the many types of polymers utilised in in situ gels, their gel formation mechanisms, and evaluation of polymeric in situ gels.

Keywords: In situ gels, ophthalmic administration, Polymers, pH shift.