European Journal of Biomedical and Pharmaceutical Sciences

NOVEL SYNTHESIS AND STUDY OF IMPACT OF CHLOROSUBSTITUTED 4-AROYL/ALKOYL PYRAZOLES AND ITS NANOPARTICLES ON PHYTOTIC GROWTH OF SOME FLOWERING PLANTS

Chhaya D. Badnakhe and M. W. Bhade*

ABSTRACT

Aroyl/alkoylacetophenones (2a-b) undergoes intramolecular claisen condensation to form 1-(2’- hydroxy-3’,5’-dichlorophenyl)-3-aryl/alkyl-1,3-propanediones (4a-b) which on treatment with aromatic and aliphatic aldehydes in ethanol containing little piperidine forms 3-aroyl/alkoylchromanones (5a-b) subsequently 3-aroyl/alkoylchromones (6a-b). 3-Aroyl/alkoylchromones (6a-b) on treatment with Ph.NH.NH2.HCl in DMSO containing small amount of piperidine gave 4-aroyl/alkoylpyrazoles (7a-b). The structures of newly synthesized chlorosubstituted 4-aroyl/alkoyl- pyrazoles (7a-b) were elucidated on the basis of molecular weight, elemental analysis and their spectral data. The titled compound and its nanoparticles were screened for their growth promoting activity on some flowering plants viz..Crysanthemum coronarium, Dahalia pinnata, Verbena officinalis, Iberis amara.

Keywords: Chromanones, Chromones, Pyrazoles, growth promoting activities.