Abstract
FORMULATION AND EVALUATION OF OPHTHALMIC IN-SITU GELS CONTAINING OFLOXACIN AND DEXOMETHASONE

Tirumaladevi .V, Alekya .T, G.Lakshmana Murthy, K. Sravya, K.Swathi Krishna, C.Roosewelt, P.Kranthi Kumar

ABSTRACT

In ocular delivery the physiological constraints imposed by the protective mechanisms of the eye lead to low absorption of drugs, resulting in a short duration of the therapeutic effect, poor bioavailability exhibited by these conventional eye drops. Thus the rapid pre corneal elimination of the drug can be overcome by these in situ gelling systems that are instilled as drops into the eye and undergo a sol-to-gel transition in the cul-de-sac and improves the residence time of the drug in the eye is increased, bioavailability and patient compliance compare to eye drops. The purpose of the present research work was the optimization and evaluation of pH induced ophthalmic in-situ gel of Ofloxacin and Dexamethasone. The in-situ gel formulation were prepared by simple mixing method based on the pH triggering system by incorporation of various polymers like HPMC and Carbopol-940 in different proportions. The in-situ gel characteristics were evaluated for Clarity, gel pH, gel Capacity, Viscocity,sterility testing and in-vitro drug release studies.

Keywords: Opthalamicin-situ gel, Ofloxacin, Dexamethasone,Carbopol-940, HPMC, pH-triggered.


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