FORMULATION AND EVALUATION OF OPHTHALMIC IN-SITU GELS CONTAINING OFLOXACIN AND DEXOMETHASONE
Tirumaladevi .V, Alekya .T, G.Lakshmana Murthy, K. Sravya, K.Swathi Krishna, C.Roosewelt, P.Kranthi Kumar
ABSTRACT
In ocular delivery the physiological constraints imposed by the
protective mechanisms of the eye lead to low absorption of drugs,
resulting in a short duration of the therapeutic effect, poor
bioavailability exhibited by these conventional eye drops. Thus the
rapid pre corneal elimination of the drug can be overcome by these in
situ gelling systems that are instilled as drops into the eye and undergo
a sol-to-gel transition in the cul-de-sac and improves the residence time of the drug in the eye
is increased, bioavailability and patient compliance compare to eye drops. The purpose of the
present research work was the optimization and evaluation of pH induced ophthalmic in-situ
gel of Ofloxacin and Dexamethasone. The in-situ gel formulation were prepared by simple
mixing method based on the pH triggering system by incorporation of various polymers like
HPMC and Carbopol-940 in different proportions. The in-situ gel characteristics were
evaluated for Clarity, gel pH, gel Capacity, Viscocity,sterility testing and in-vitro drug release
studies.
Keywords: Opthalamicin-situ gel, Ofloxacin, Dexamethasone,Carbopol-940, HPMC, pH-triggered.
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