European Journal of Biomedical and Pharmaceutical Sciences

A STUDY ON FORMULATION OF A NOVEL HERBAL TREATMENT FOR PEPTIC ULCER

*Satbir Singh and Dr. Gaikwad Dushyant Dadabhau 

ABSTRACT

It has been demonstrated that extracts of Curcuma longa, Piper nigrum, and Berberis aristata are effective in treating stomach disorders and exhibit antiulcer properties. Since treatment for peptic ulceration involves the ingestion of multiple herbs, their effects are synergistic compared to those of a single herb. This project's objective was to keep herbal extract-based gastroretentive formulations in the stomach for improved antiulcer activity. Therefore, formulation and evaluation of a spray-dried extract of Curcuma longa, Piper nigrum, and Berberis aristata floating tablet were conducted. In most instances, gastric lesions that develop in the upper portion of the gastrointestinal tract and are characterized by an imbalance between acid and mucin, characterize peptic ulcer. The purpose of this study is to develop and evaluate herbal formulations containing Curcuma longa, Berberis aristata, and Piper nigrum. As a single drug or in combination with other drugs, these are reported to be effective in treating peptic ulcer. Curcumin extracted from Curcuma longa has gastroprotective and antiulcerogenic properties. Piperine, an active component of Piper nigrum, has bioenhancer and antiulcer properties. Berberine from Berberis aristata inhibited the growth of H. pylori and the N-acetyltransferase activity of H. pylori.

Keywords: Formulation, Herbal Treatment, Peptic Ulcer, Stomach.