European Journal of Biomedical and Pharmaceutical Sciences

NANOSPONGES-REVOLUTIONIZING TARGETED DRUG DELIVERY SYSTEM

Rushikesh Ruprao Gawai* and Gauri Pramod Gawande, Swati P. Deshmukh

ABSTRACT

Nanosponges are small, porous particles with 1-2 nanometer pores suitable for drug delivery, detoxification, and environmental cleanup. They are non-toxic, stable at high temperatures, and can selectively release chemicals due to their 3D structure. Composed of polymer, surfactant, drug substance, and solvent with advantages like compatibility, self-sterilization, free flow, extended-release action, oil control, high entrapment effectiveness, and improved product performance. Nanoparticles are materials with various properties and applications, including titanium dioxide (tio2), silicon, hyper-cross-linked polystyrene, cyclodextrin nanosponges (cdns), and polyamidoamine nanosponges. They are biodegradable, specific polyester structures that release drugs over time. Preparation methods include melt, solvent, ultrasound-assisted synthesis, quasi-emulsion diffusion, drug loading, and emulsion solvent diffusion. Nanosponges are a cutting-edge drug delivery system that improves the solubility of poorly water-soluble medications. They offer high solubility. Nanosponges can enhance drug solubility by over 27 times, and polyvinyl pyrrolidone adds 55 times, resulting in faster drug dissolution profiles. They are also used for drug delivery, protein delivery, cancer therapy, antiviral applications, gas delivery systems, water purification, biomedical engineering, drug release modulation, enzyme immobilization, targeted delivery, and diagnostic applications. Nanosponges have potential therapeutic and diagnostic applications, including treating cardiovascular disease a atherosclerotic plaques. In conclusion, nanosponges are a promising method for treating cancer, improving site-specific drug delivery, and enhancing the effectiveness of medications. Future advancements in healthcare could follow nanosponge technology, which could be a valuable tool for preventative care. With its prolonged and safe actions, nanosponges have a keen interest in contemporary medicine and research.

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