European Journal of Biomedical and Pharmaceutical Sciences

NEPHROPROTECTIVE ACTIVITY OF WHOLE PLANT OF TEPHROSIA PURPUREA BY CISPLATIN INDUCED METHOD

Dr. Dev Prakash*, Pavitra Solanki and Dr. K. K. Sreenivasan

ABSTRACT

Tephrosia purpurea (Family Fabaceae) is commonly known as Sarphank. The plant has been claimed to cure diseases of kidney, liver, spleen, heart and blood. The aim of the present study was to determine the nephroprotective activity of ethanolic extracts of the whole plant of Tephrosia purpurea. The cisplatin induced nephrotic models were used for the study. Animals were divided into different group control, standard, and test group after IAEC approval. Final results of different groups were compared (results of the extract (250 mg/kg, 500 mg/kg) with that of standard drug. On the basis of experimental data obtained, it was observed that the whole plant extract at the dose of 250 mg/kg and 500 mg/kg showed significant nephroprotective activity and the activity was found to be maximum at 500 mg dose extract. It means that the effect was found to vary in a dose dependent way. The result suggests that the ethanolic extract from the whole plant of Tephrosia purpurea exhibited significant dose dependant nephroprotective activity.

Keywords: Tephrosia purpurea, Nephroprotective, Cisplatin.