European Journal of Biomedical and Pharmaceutical Sciences

IN SILICO APPROACHES FOR ASSESSING THE IMPACT OF DELETERIOUS NSSNPS ON PROTEIN FUNCTION AND DRUG RESPONSE: BRIDGING PHARMACOGENOMICS AND PROTEIN STRUCTURE ANALYSIS

Sathishkumar A.*, Saisudha S., Mohanapriya K., Balasubramaniyam P. N. and Ahamed Mueen M.

ABSTRACT

Genetic variants allowing amino acid substitutions in proteins are termed nonsynonymous single-nucleotide polymorphisms (nsSNPs). It is possible for nsSNPs to have a large impact on human health due to their effect on protein structure and function. In the same way, polymorphisms in genes that encode drug targets play a profound role in drug response, either by directly affecting drug target function or by interfering with drug-target interaction. Pharmacogenomics explains how polymorphisms can have a significant impact on drug response, including the ability to produce potentially fatal adverse outcomes as well as equally severe lacks of therapeutic responses. During this review, deleterious nsSNPs are discussed both at the Protein structure and function are determined by a number of factors, including their effects on protein-protein interactions. Structure and properties of amino acids based on physicochemical properties are also used in order to predict how nsSNPs will affect function. Additionally, Pharmacogenomics in silico, which provides understanding of the phenotypic characteristics of diseases and individuals susceptibilities, is discussed. Using Our knowledge of these factors will soon allow us to determine the most effective treatment and drug therapy. In conclusion, this essay discusses how in silico approaches can be used to assess and develop drugs that are safe and effective.

Keywords: Drug responses, drug-target proteins, pharmacogenomics, not-synonymous nucleotide polymorphisms, personalized medicine.