Abstract
IN VITRO CYTOTOXICITY OF ETHANOLIC LEAF EXTRACT OF ALTERNANTHERA SESSILIS (L.) R.BR. EX DC AND ALTERNANTHERA PHILOXEROIDES (MART.) GRISEB AGAINST HUMAN OSTEOSARCOMA CELL LINE MG-63

D. Sunmathi* and Dr. R. Sivakumar

ABSTRACT

Crude ethanolic leaf extracts of Alternanthera sessilis and Alternanthera philoxeroides were examined for their anticancer activity. To determine anticancer activity, different concentrations of crude extracts were tested on MG- 63, a humanosteosarcoma cell-line by 3-(4, 5 dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Alternanthera philoxeroides extract showed a significant antiproliferative activity than Alternanthera sessilis and a dose dependent effect was observed. Maximum inhibition of 67.37% was observed for Alternanthera philoxeroides and 47.7% for Alternanthera sessilis at 300μg/ml. The results indicate the possible potential use of these plants in cancer theraphy.

Keywords: Alternanthera sessilis, Alternanthera philoxeroides, MG-63, MTT assay.


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