European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF SUSPENSION FOR TREATMENT OF INTESTINAL PARASITIC WORMS AND MALNUTRITION USING CARICA PAPAYA EXTRACTS

Dhiraj D. Malunjkar*, Dr. Avish D. Maru, Dr. Santosh S. Surana

ABSTRACT

Soil Transmitted Helminthes (STH) is one of the world's most underappreciated tropical illnesses. Morbidity from STHs is highest in school-aged children, who have the highest infection. In 2001, the World Health Organisation (WHO) approved a resolution for large-scale mass drug administration (MDA), i.e. albendazole suspension, to deworm vulnerable children through school-based programmes. Because of the presence of Benzyl isothiocyanate, the seeds and fruits of Carica papaya have anthelmintic qualities. Due to the harsh taste of Carica papaya seed, it is necessary to convert it into an appropriate dosage form, such as seed suspension, which enhances patient compliance with dosage form. For formulation of suspension Carica papaya seed powder is used as an active agent and Carboxymethylcellulose sodium is used as suspending agent to varying its concentration (0.5%, 1%, and 1.5%) this may effect on its viscosity and stability of suspension. By performing In-Vitro Anthelmintic study it is found that Carica papaya seeds have ability to treatment of helminthic infection and by increasing the concentration of Carboxymethylcellulose sodium the viscosity and stability of suspension is increases. All the evaluation parameters of suspension are found to be satisfactory and In-Vitro Anthelmintic study shows the helminthic property of suspension. The stability studies are performed for the one month no significant changes are observed during stability. Hence our suspension has advantage over the helminths.

Keywords: Carica papaya, Helminthes, Benzyl isothiocyanate, Suspension, Stability.