DEVELOPMENT OF NEW AND NOVEL ANALYTICAL METHODS OF AND ITS VALIDATION OF VALSARTAN IN PURE AND PHARMACEUTICAL DOSAGE FORM BY UV-SPECTROMETRY METHOD
Mohanraj P.*, Amudhavalli K. and Perumal P.
ABSTRACT
Objective: Using a UV-spectrometry method, develop new and innovative analytical techniques and validate them for use with pharmaceutical dosage forms of valsartan. Methods: Wavelength selection Stock solution preparation 40 mg of the medicine were dissolved in ethanol to create the standard stock solution for Valsartan, which was then further diluted with distilled water. Once the solution had a concentration of 10, 20, 30, 40, 50, or 60 g/ml, it was further diluted. Between 200 and 400 nm in the UV spectrum, the solutions were scanned. range for Beer's law concentration By dissolving 100 mg of the drug in ethanol, mixing it with the same solvent, and then diluting it further with distilled water, a standard stock solution of valsartan was created with a concentration range of 1 to 100 g/ml. The solutions were scanned in the 200-400 nm range of the UV spectrum, and their absorbance was determined at 250.0 nm. A calibration curve was created between 10 and 60 g/ml using absorbance values versus concentrations. Results: The wavelength with the highest absorbance was chosen as the wavelength after preparing a concentration of 10-60 g/ml standard stock solution and observing the absorbance at various wavelengths. Conculsion: The article presents a UV Spectrophotometric approach for Valsartan dosage estimation in both pure and pharmaceutical form.
Keywords: Valsartan, UV Spectroscopy, Method development, Validation, and Estimation are some of the key phrases.
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