Abstract
EVALUATION OF ACUTE DERMAL IRRITATION AND CORROSION EFFECTS OF BOSWELLIA SERRATA (BOSWEGEX®) FOR TOPICAL APPLICATION IN HEALTHY NEW ZEALAND WHITE RABBITS

Vadiraj G. B.*, C. A. Anzar, Joseph M. V.1, Dr. Sundaram R., Prasad C. P. and Bineesh Eranimose

ABSTRACT

Boswellia serrata (Boswegex®) is a herbal extract that has been standardised for treating pain and inflammation. The objective of this research was to assess Boswegex®'s skin irritation and corrosion in New Zealand white rabbits. The effect of each treatment of Boswegex® was recorded for 14 days on the rabbits' dermally exposed skins. During the observation period, clinical signs and body weight were also examined in addition to the evaluation of the skin reactions (erythema and edema) in accordance with local toxic effects. The reactions were evaluated after 60 minutes, then at 24, 48, and 72 hours after the patch was removed, and the animals were further examined for erythema and edema. In a single exposure test, Boswegex® did not cause any reactions on healthy skin spaces after its application and the subsequent 14-day observation period. Thus, Boswegex® could potentially be regarded as non-irritating and secure for use on rabbit skin. Therefore, topical Boswegex® could be applied to the skin without causing any sensitivity.

Keywords: Boswellia serrata (Boswegex®), New Zealand white rabbits, Skin corrosion, Skin irritation.


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