European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND STUDY OF IMIDAZOLE DERIVATIVES OF ARYL SUBSTITUTED 1,3-THIAZOLES AND THEIR NANOPARTICLES ON PHYTOTIC GROWTH OF SOME VEGETABLE CROPS

Chhaya D. Badnakhe*

ABSTRACT

The synthesis, spectral analysis and biological activities of 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one- 2-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (8d2) (J”) have been carried out. In this case 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(heptan-1-one)-2- amino-1,3-thiazole (8d) (J), 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one-2-[(2-hydroxy-3,5-dichlorophenyl)ethanonylamino]-1,3-thiazole (8d1) (J’) & 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one- 2-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (8d2) (J”) have been screened. The compound (J) was synthesized from 1-(2’-Hydroxy-3’,5’-dichlorophenyl)-2-bromo-1,3-nonanedione (a4) by the action of thiourea, while (J”) was synthesized from (J) by reaction with α-bromo,2-hydroxy-3,5 dichloroacetophenone to get 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one-2-[(2-hydroxy-3,5-dichlorophenyl)ethanonylamino]-1,3-thiazole (8d1) (J’). Further (J’) on treatment with KSCN was dissolved in acetic acid gave (J’’). The nanoparticles of the compounds J, J’and J’’ have been prepared by using ultrasonic technique. The titled compounds and their nanoparticles were screened for their growth promoting activity on some vegetable crop plants viz. Momordica charantia-L-Bitter guard (Karela), Lagneria siceraria-snake guard (Lavki), Luffa cylindrica L-sponge guard (Gilke) and Benincasa hispida-Pumpkin (Kohle).

Keywords: Chalcone, thiazine, thiourea, ?-bromo,2-hydroxy-3,5 dichloroacetophenone, KSCN was dissolved in acetic, growth promoting activities.