FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF ANTI VIRAL DRUG GASTRORETENTIVE MICROSPHERES
Lakkineni Pavankumar, V. Jhansi Priya Marabathuni* and Naidu Narapusetty
ABSTRACT
The present work was the Formulation Development and In-Vitro Evaluation Of lopinavir Gastroretentive Microspheres. Different polymers like sodium alginate, sodium carboxy methyl cellulose, HPMC K4M, HPMC K100M were utilized in the trials. All the physical evaluations are carried in preformulation studies were carried out on all the three different polymers utililized. All the formulations exhibited values within the acceptable range. Microspheres were evaluated for buoyancy studies, drug entrapment efficient. Release studies were carried out in 0.1N HCL for 12 hours. Evaluated samples for all the four polymer system. Results indicated that formulation F7, gave 90.12 % release up to 12 hrs which is formulated with HPMC K100M and HPMCK4M combination. Assay was carried out for formulation F7 and was found to be 88.69 %. The mechanism of drug release from microspheres follows Non-Ficknian release. Remaining formulations gave fluctuating release profiles. The formulation F7 was considered to be better among the trails accomplished.
Keywords: Gastroretentive Microspheres, buoyancy studies, drug entrapment efficient, kinetic studies.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
