European Journal of Biomedical and Pharmaceutical Sciences

MICROWAVE ASSISTED SYNTHESIS OF SOME INDOLE BASED (1H-INDOL-3-YL)-NMETHYL/ PHENYL-PYRAZOLIDIN PYRAZOLE DERIVATIVES AND THEIR ANTIINFLAMMATORY ACTIVITY

Deepak Swarnkar*, Rakshit Ameta and Ritu Vyas

ABSTRACT

In the present investigation, microwave assisted synthesis of Chalcones (3a-b) were synthesized by base catalyzed aldol condensation of indole-3-carbaldehyde (1) with acetone or acetophenone (2a-b) in the presence of piperidine. The mixture of Chalcones (3a-b) was carried out with 1H-indole-2-carbhydrazide (7a-e), prepared by reaction of 1H-indole-2-carboxylic acid (4) and conc. H2SO4 exposed in microwave to get ethyl indole-2- carboxylate ester (5) then react with corresponding hydrazines (6a-e) in ethanol containing a few drops of glacial acetic acid under microwave irradiation to get target compounds (8a-j). The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR and 1H NMR spectral data. The synthesized compounds have been screened for their anti-inflammatory activity.

Keywords: Chalcones, Indole, Pyrazole, Microwave irradiation, Anti-inflammatory activity.