European Journal of Biomedical and Pharmaceutical Sciences

OFLOXACIN INDUCED TEN - A CASE REPORT

Ramana Mulagundla, Sandeep Ankam*, Manasa Bollampally

ABSTRACT

Toxic epidermal necrolysis (TEN) is a potentially life-threatening dermatologic disorder characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and/or death. The development of TEN in this patient has been initiated by the intake of oral ofloxacin, and the subsequent treatment with oral diclofenac may have increased his adverse reactions. Practitioners should be aware of this rare serious adverse event, especially ofloxacin is commonly used for Pneumonia, skin and soft tissue infections and genitourinary infections. Close follow-up with patients to evaluate these adverse reactions, especially in case of quinolones. Cutaneous drug eruptions are one of the most frequent manifestations of adverse drug reactions, seen in 2-3% of hospitalised patients.

Keywords: Cutaneous drug eruptions, Toxic epidermal necrolysis (TEN), Ofloxacin.