European Journal of Biomedical and Pharmaceutical Sciences

DESIGN, SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDIES AND BIOLOGICAL EVALUATION OF BENZIMIDAZOLE CONTAINING 4H-CHROMEN-4-ONE DERIVATIVES

Roshani Geed*, Dr. Govind Nayak and Dr. Parul Mehta

ABSTRACT

Benzimidazole is an interesting pharmacophore which has been extensively studied in medicinal chemistry due to its high affinity towards various enzymes and receptors. Its derivatives have been previously shown to possess a wide range of biological activities including anthelmintic, antihypertensive, antiulcer, as well as anticholinesterase activity. Benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the pharmaceutical industry for drug discovery. Due to their special structural features and electron-rich environment, Benzimidazole containing drugs bind to a variety of therapeutic targets, thereby exhibiting a broad spectrum of bioactivities. Numerous benzimidazole based drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potential. The present study focuses on the design and synthesize of a novel class of (E)-2-(2-(5-nitro-1H-benzo[d]imidazol-2-yl)vinyl)-4H-chromen-4-one derivatives and the characterization was done using IR, 1H NMR, 13C NMR, and mass spectroscopy. Further these novel set of compounds were screened for various pharmacological activities.

Keywords: IR, 1H NMR, 13C NMR, and mass spectroscopy.