European Journal of Biomedical and Pharmaceutical Sciences

DEVELOPMENT AND CHARACTERIZATION OF KETOROLAC TRANSDERMAL PATCHES

Ayesha Binth Abdullah*, K. Ravi Teja, Dr. A. Yashodha and K. Jyothi

ABSTRACT

The objective of present study was to develop matrix type transdermal therapeutic systems of Ketorolac using various hydrophilic and hydrophobic polymers as matrix formers. Results revealed that prepared patches showed good physical characteristics, no drug-polymer interaction and no skin irritation was observed. The in vitro release study revealed that F7 formulation showed maximum release in 8 hrs. Formulation F7 was subjected for accelerated stability studies. The F7 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches, which was also confirmed by FTIR. Thus conclusion can be made that stable transdermal patches of Ketorolac has been developed. F8 formulations showed highest cumulative percentage drug release of 96.30% were obtained during in vitro drug release studies. The predominant release mechanism of drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F7 formulation was concluded as optimized formulation.

Keywords: Ketorolac, Polymers, FTIR studies solvent casting technique, In-vitro drug release studies.