European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, IN-VITRO ANTIMICROBIAL EVALUATION AND DOCKING STUDY OF 9-(SUBSTITUTED-BENZYLIDENE)-2-METHOXY-9, 10-DIHYDRO-ACRIDINE ANALOGUES

Ramesh Kumar*

ABSTRACT

In this study six 9-(Substituted-Benzylidene)-2-methoxy-9, 10-dihydro-acridine analogues were prepared by the procedure as reported in literature. The characterization of compounds was done by their physicochemical and spectral means (IR and 1HNMR). The synthesized compounds were further screened for their antimicrobial activity against different microbial strains viz. S. aureus, B. subtilis (Gram positive), and P. aeruginosa, E. coli (Gram negative) bacteria and C. albican, A. niger fungal strain. Among these synthesized compounds, some of the compounds showed significant antibacterial and antifungal activity. Docking study of the two compounds showing maximum activity, were carried out by Autodock vina on protein Thymidylate kinase (TMPK).

Keywords: Acridine, antimicrobial, antibacterial, antifungal.