Abstract
THE LEAF EXTRACT OF MUNTINGIA CALABURA EXHIBITS IN VITRO ANTIDIABETIC POTENTIALS BY THE SENSITIZATION OF INSULIN

Subhajit Dutta*, Ramesh C, Pinkey Rawal, Sowmya B.A, Pundi Krishna

ABSTRACT

The objective of the current study was to evaluate the mechanism through which Muntingia calabura exerts its antidiabetic effects. Materials &Methods: The authenticated leaves of plant Muntingia calabura were dried and powdered. The powdered drug was defatted using petroleum ether, and extracted with ethanol. An initial phytochemical analysis of Muntingia calabura's ethanol extract was performed. The rat hemi-diaphragm (skeletal muscle) model for glucose uptake was also employed to assess the potential of an ethanol extract of Muntingia calabura to improve peripheral tissue uptake of blood glucose. The albino rat that had been fasting the previous night was slaughtered and its hemidiaphragm was removed. The amount of glucose used by the tissue was calculated after weighing a portion of skeletal muscle and incubating it with glucose in Tyrode solution for 30 mins at 37oC. Results: The skeletal muscle's ability to use glucose was greatly improved by the ethanol extract of Muntingia calabura, which also has the ability to make insulin more sensitive. Conclusion: The findings of the current study suggest that decreasing insulin resistance is one of the ways through which the ethanol extract of Muntingia calabura exerts its anti-diabetic effects.

Keywords: Antidiabetic activity, Muntingia calabura, Hemidiaphragm, Glucose utilization.


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