European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF DICLOFENAC ON THE PHARMACOKINETICS OF SULPHADIMIDINE IN WEST AFRICAN DWARF (WAD) GOATS FOLLOWING INTRAMUSCULAR ADMINISTRATION

*Agbo J. O., Onyeyili P. A., Saganuwan S. A. and Bosha J. A.

ABSTRACT

Sulphadimidine an antimicrobial is widely used in veterinary medicine in the treatment of animal diseases. It can be combined with non-steroidal anti-inflammatory drugs to treat various systemic infections associated with fever, pain and other inflammatory conditions. This study was carried out to determine the effect of diclofenac on the pharmacokinetics of sulphadimidine in West African Dwarf goats. Eight (8) WAD goats of 1-2 years old with a mean weight of 17.73 0.89 kg were separated into two groups of four animals consisting of two males and two female goats each. Sulphadimdine sodium (33.3%) was administered at a dose of 100 mg/kg body weight and diclofenac (2.5%) was administered at a dose of 2.5mg/kg body weight. Sulphadimidine was administered into the right gluteal muscle to goats in group 1. To the goats in group 2, sulphadimidine was administered into the right gluteal muscle and diclofenac into the left gluteal muscle concurrently. There was no significant difference (p>0.05) in pharmacokinetic parameters between the WAD goats treated with sulphadimidine alone and sulphadimidine co-administered with diclofenac. Based on the results obtained, it can be concluded that diclofenac can be safely and effectively combined with sulphadimidine to treat animal diseases associated with fever, pain and other inflammatory conditions.

Keywords: Sulphadimidine, West African Dwarf goats, Diclofenac, Pharmacokinetics.