European Journal of Biomedical and Pharmaceutical Sciences

HISTORICAL AND FUTURE DIRECTIONS IN WOUND HEALING THERAPY

Mohamed Raouf Mohamed*, Khaled Aly Khaled, Hamza Abdel Raouf and Usama Farghaly Aly

ABSTRACT

Wounds can be classified based on the time at which it heals as acute and chronic. An acute wound is an injury that causes a break in the skin and it occurs suddenly, last a short time, and may heal on its own. A chronic wound is a wound that does not heal in orderly set of stages and in a predictable time the way most wounds do. Chronic wound remain one of the most common and serious consequences of diabetes. Wound healing may be delayed due to abnormal cell function, hyperglycemia, peripheral neuropathy, peripheral vascular disease, susceptibility to infections and abnormal planter foot pressures. Delayed wound healing causes prolong morbidity and may ultimately end up in loss of part or whole of the foot. Treatment of chronic wound represents a significant and growing challenge. The wound-healing process consists of four integrated and overlapping phases: homeostasis, inflammation, proliferation, and tissue remodeling or resolution. Impaired wound healing is a major complication of diabetes. Many topical therapeutic agents have been used to enhance wound healing. Development of new generation wound care products is an evolving field. One of the most common agents used for wound care are topical preparations.

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