STUDIES ON THE OXIDATIVE STRESS PARAMETERS IN ORAL CANCER PATIENTS
Upasana Bhat, G. Bindu, Samer Adnan Hani Al – Khaboori, Balasubramanian Sathyamurthy*
ABSTRACT
Oral cancer in India ranks number one among all cancers in male patients and number three among cancers in
female patients in India. There are a number of substances which seem to stimulate the production of free radicals.
Enzymatic and non-enzymatic antioxidant defense systems helps to protect cells against those free radicals
produced during normal metabolism and after an oxidative insult. Alteration in any one of these systems results in
break in this equilibrium and cause cellular damages which ultimately transform the cell to malignant. Our study
in patients with oral cavity cancer reveals elevated levels of lipid peroxidation products and nitric oxide products
and effective depletion shown in the oral cancer patient. However, the degree of effectiveness with which the
antioxidant system can be restored or maintained with dietary and nutritional supplements, so that oral cancer
atients can actually be benefited remains to be elucidated. Further investigation can be continued with the same
approach in oral cancer patient of various age groups, among sex, among children. This will enlighten about the
enzymatic and non enzymatic parameters under study in above various groups and may guide us to prevent the
oral cancer.
Keywords: Oral cancer, ROS, peroxidation, glutathione.
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